As far as reading vs watching vs listening (vs playing)... I've run the gamut. As DNA himself mentioned, the only thing that can ever be certain about any new incarnation of HHGTTG is that it will most definitely contradict any and all previous incarnations of the same.
That said, no, I wouldn't discount a lady just because she...
*had read the book instead of seeing the movie
*had listened to the radio broadcasts instead of reading the book
*had watched the movie instead of reading the book or listening to the radio broadcasts
*had played the game instead of reading the book, watching the movie, or listening to the radio broadcasts
*had only listened to the movie, watched the book, danced to the radio broadcasts, and didn't realize there was a game to be played.
*has no idea what any of this means, but is curious.
*owns a TARDIS (or has at least been inside one - it's bigger on the inside)
*refuses to blink near stone sculptures - just in case
*gets frightened when she stumbles across a plunger in the closet.